A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …

Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Depression is one of the most prevalent and debilitating of the psychiatric disorders. Studies
have shown that cognitive therapy is as efficacious as antidepressant medication at treating …

Converging lines of research suggest that the hippocampal complex (HC) may have a role
in the pathophysiology of major depressive disorder (MDD). Although postmortem studies …

A thorough understanding of the cognitive effects of antidepressant medications is essential
given their frequency of use. This meta-analysis was conducted to investigate whether …

The effects of major depressive disorder (MDD) on neurocognitive function remain poorly
understood. Results from published studies vary widely in terms of methodological factors …

Several neuroimaging studies have reported 'hypofrontality'in depressed patients
performing a cognitive challenge compared to control subjects. Hypofrontality in depression …

This paper reports the results of an across lab metanalysis of effective connectivity in major
depression (MDD). Using FDG PET data and Structural Equation Modeling, a formal …

Background Depression is associated with interpersonal difficulties related to abnormalities
in affective facial processing. Objectives To map brain systems activated by sad facial affect …