Regulation of ligands for the NKG2D activating receptor

DH Raulet, S Gasser, BG Gowen… - Annual review of …, 2013 - annualreviews.org
NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …

NK cell recognition

LL Lanier - Annu. Rev. Immunol., 2005 - annualreviews.org
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The C‐type lectin‐like domain superfamily

AN Zelensky, JE Gready - The FEBS journal, 2005 - Wiley Online Library
The superfamily of proteins containing C‐type lectin‐like domains (CTLDs) is a large group
of extracellular Metazoan proteins with diverse functions. The CTLD structure has a …

How TCRs bind MHCs, peptides, and coreceptors

MG Rudolph, RL Stanfield, IA Wilson - Annu. Rev. Immunol., 2006 - annualreviews.org
Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

Roles of the NKG2D immunoreceptor and its ligands

DH Raulet - Nature Reviews Immunology, 2003 - nature.com
According to present concepts, innate immunity is regulated by receptors that determine
danger levels by responding to molecules that are associated with infection or cellular …

NK cells and cancer immunosurveillance

I Waldhauer, A Steinle - Oncogene, 2008 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system that monitor cell
surfaces of autologous cells for an aberrant expression of MHC class I molecules and cell …

Immune functions encoded by the natural killer gene complex

WM Yokoyama, BFM Plougastel - Nature Reviews Immunology, 2003 - nature.com
There has been marked progress in our understanding of the role of natural killer (NK) cells
in immune responses, mainly due to the identification of NK-cell receptors and their ligands …

Modulation of innate and adaptive immunity by cytomegaloviruses

R Berry, GM Watson, S Jonjic… - Nature reviews …, 2020 - nature.com
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I–like molecules

EJ Adams, AM Luoma - Annual review of immunology, 2013 - annualreviews.org
The MHC fold is found in proteins that have a range of functions in the maintenance of an
organism's health, from immune regulation to fat metabolism. Well adapted for antigen …

Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D

LN Carayannopoulos, OV Naidenko… - The Journal of …, 2002 - journals.aai.org
Murine NKG2D is known to recognize H60 and five RAE1 variants. The human homologue
recognizes both inducible MHC class I chain-related gene and constitutive (UL16-binding …