T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show
that lung remodeling from a prior infection with a lung-migrating helminth, Nippostrongylus …

Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …

Virtual memory T (TVM) cells are a T cell subtype with a memory phenotype but no prior
exposure to foreign antigen. Although TVM cells have antiviral and antibacterial functions …

The immunological hallmarks of sepsis include the inflammation-mediated cytokine storm,
apoptosis-driven lymphopenia, and prolonged immunoparalysis. Although early clinical …

Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct
effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this …

Virtual memory cells (VM) are an antigen-specific, memory phenotype CD8 T-cell subset
found in lymphoreplete, unchallenged mice. Previous studies indicated that VM cells were …

Memory-phenotype CD8+ T cells exist in substantial numbers within hosts that have not
been exposed to either foreign antigen or overt lymphopenia. These antigen-inexperienced …

Regulatory T cells (Tregs) play a key role in the peripheral self‐tolerance and preventing
autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ …