Frontotemporal dementia (FTD) is a highly heritable group of neurodegenerative disorders,
with around 30% of patients having a strong family history. The majority of that heritability is …

The frontotemporal tauopathies all deposit abnormal tau protein aggregates, but often of
only certain isoforms and in distinguishing pathologies of five main types (neuronal Pick …

Developing and validating sensitive biomarkers for the presymptomatic stage of familial
frontotemporal dementia is an important step in early diagnosis and for the design of future …

Background Epidemiologic studies have shown that Alzheimer's disease (AD) and related
dementias (ADRD) are seen more frequently with asthma, especially with greater asthma …

The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and
encompass a long accrual of progressive biological (preclinical) and then clinical …

Background Microglial dysfunction is implicated in frontotemporal lobar degeneration
(FTLD). Although studies have reported excessive microglial activation or senescence …

Objective Progranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive
disease. Modelling the cascade of multimodal biomarker changes aids in understanding the …

Objective To identify novel CSF biomarkers in GRN‐associated frontotemporal dementia
(FTD) by proteomics using mass spectrometry (MS). Methods Unbiased MS was applied to …

More than half of the human brain volume is made up of white matter: regions where axons
are coated in myelin, which primarily functions to increase the conduction speed of axon …

Objective MAPT mutations typically cause behavioral variant frontotemporal dementia with
or without parkinsonism. Previous studies have shown that symptomatic MAPT mutation …