The epidemic of the century, Diabetes Mellitus (DM) is continuously rising. Intensive
research is urgently needed whereby experimental models represent an essential tool to …

Diet is a critical element determining human health and diseases, and unbalanced food
habits are major risk factors for the development of obesity and related metabolic disorders …

Background and Aims Although the majority of patients with non-alcoholic fatty liver disease
(NAFLD) have only steatosis without progression, a sizeable fraction develop non-alcoholic …

Obesity represents the most important single risk factor in the pathogenesis of type 2
diabetes, a disease which is characterized by a resistance to insulin-stimulated glucose …

Aims Exercise is beneficial in obesity, however, the debate about the value of high-intensity
interval training (HIIT) vs. moderate-intensity continuous training (MICT) has been long …

Our objective was to establish a diabetes mellitus type 2 (DM2) model in rats using a high-fat
diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control …

Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

Background Eugenol, a phenolic compound present in many plant essential oils,
demonstrated anti-diabetic activity but the underlying mechanisms are not fully understood …

Early-life stress is associated with depression and metabolic abnormalities that increase the
risk of cardiovascular disease and diabetes. Such associations could be due to increased …

Summary Type 2 diabetes (T2D) develops after years of prediabetes during which high
glucose (glucotoxicity) impairs insulin secretion. We report that the ATP-conducting …