Abstract Three-dimensional (3D) in vitro models have been used in cancer research as an
intermediate model between in vitro cancer cell line cultures and in vivo tumor. Spherical …

This review provides a balanced integration of the most recent chemical, biochemical and
medical information on the unique characteristics of chitins and chitosans in the area of …

The establishment of an early pro-regenerative niche is crucial for tissue regeneration,.
Gasdermin D (GSDMD)-dependent pyroptosis accounts for the release of inflammatory …

Biological Roles of Fibroblast Growth Factor-2* | Endocrine Reviews | Oxford Academic
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FGF signaling plays a ubiquitous role in human biology as a regulator of embryonic
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling …

Providing comprehensive coverage of the biological activities and industrial applications of
Chitin, Chitosan, oligosaccharides, and their derivatives, this book presents a balance of …

Publisher Summary This chapter discusses the structural aspects and structure–activity
relationships of heparin/heparan sulfate (HS). The molecular mechanism behind the …

The activity of fibroblast growth factor 2 (FGF-2) is stringently controlled. Inactive in
undisturbed tissues, it is activated during injury and is critical for tissue repair. We find that …

The Drosophila sugarless and sulfateless genes encode enzymes required for the
biosynthesis of heparan sulfate glycosaminoglycans. Biochemical studies have shown that …

Cancer stem cells (CSCs) are tumor cells with initiating ability, self‐renewal potential, and
intrinsic resistance to conventional therapeutics. Efficient isolation and characterization of …