Therapeutic potential of quercetin: new insights and perspectives for human health

B Salehi, L Machin, L Monzote, J Sharifi-Rad… - ACS …, 2020 - ACS Publications
Quercetin (Que) and its derivatives are naturally occurring phytochemicals with promising
bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti …

Mitochondria as potential targets in Alzheimer disease therapy: an update

G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Natural dietary supplementation of anthocyanins via PI3K/Akt/Nrf2/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse …

T Ali, T Kim, SU Rehman, MS Khan, FU Amin… - Molecular …, 2018 - Springer
Well-established studies have shown an elevated level of reactive oxygen species (ROS)
that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal …

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

E Zaplatic, M Bule, SZA Shah, MS Uddin, K Niaz - Life sciences, 2019 - Elsevier
Quercetin belongs to the flavonoids family, which is present in most of the plants including
fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available …

Flavonoids as therapeutic agents in Alzheimer's and Parkinson's diseases: a systematic review of preclinical evidences

RB de Andrade Teles, TC Diniz… - Oxidative medicine …, 2018 - Wiley Online Library
Alzheimer's and Parkinson's diseases are considered the most common neurodegenerative
disorders, representing a major focus of neuroscience research to understanding the …

Hesperetin confers neuroprotection by regulating Nrf2/TLR4/NF-κB signaling in an Aβ mouse model

M Ikram, T Muhammad, SU Rehman, A Khan… - Molecular …, 2019 - Springer
Hesperetin is a bioactive flavonoid in the body, produced from hesperidin. No
comprehensive studies have shown its protective effects in neurodegenerative disorders …

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

S Chen, Y Tang, Y Gao, K Nie, H Wang, H Su… - Frontiers in …, 2022 - frontiersin.org
Depression is a global health problem with growing prevalence rates and serious impacts
on the daily life of patients. However, the side effects of currently used antidepressants …

Neuroprotective role of phytochemicals

BK Velmurugan, B Rathinasamy, BP Lohanathan… - Molecules, 2018 - mdpi.com
Neurodegenerative diseases are normally distinguished as disorders with loss of neurons.
Various compounds are being tested to treat neurodegenerative diseases (NDs) but they …

Neuroprotective potentials of Lead phytochemicals against Alzheimer's disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic …

M Ayaz, OF Mosa, A Nawaz, AAE Hamdoon… - Phytomedicine, 2024 - Elsevier
Background Alzheimer's diseases (AD) and dementia are among the highly prevalent
neurological disorders characterized by deposition of beta amyloid (Aβ) plaques, dense …

Enhancing the potential preclinical and clinical benefits of quercetin through novel drug delivery systems

R Khursheed, SK Singh, S Wadhwa, M Gulati… - Drug discovery today, 2020 - Elsevier
Highlights•Pharmacological activities and molecular targets of quercetin.•Mechanistic
pathways of quercetin for treating different diseases.•Formulation strategies for improving …