Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

Focusing on previously published mechanisms of non-alcoholic fatty liver disease (NAFLD),
their uncertainty does not always permit a clear elucidation of the grassroot alterations that …

Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid
transport, synthesis, and metabolism. However, the molecular mechanism and physiological …

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally. NAFLD
includes non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). NASH is …

Lipotoxicity causes hepatic cell death and therefore plays an important role in the
pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metformin, a first-line anti …

Objective To determine the role of fatty acid oxidation on the cellular, molecular, and
physiologic response of brown adipose tissue to disparate paradigms of chronic …

Perturbation of mitochondrial proteostasis provokes cell autonomous and cell non-
autonomous responses that contribute to homeostatic adaptation. Here, we demonstrate …

Metabolic-associated steatotic liver disease (MASLD) is a cluster of pathological conditions
primarily developed due to the accumulation of ectopic fat in the hepatocytes. During the …

2 Cl-PFESA is a polyfluoroalkyl ether with high environmental persistence that has been
confirmed to have significant adverse effects on animals. In this study, 6-week-old female …