Design of therapeutic biomaterials to control inflammation

Z Tu, Y Zhong, H Hu, D Shao, R Haag… - Nature Reviews …, 2022 - nature.com
Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

Advances in islet encapsulation technologies

T Desai, LD Shea - Nature reviews Drug discovery, 2017 - nature.com
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …

Engineering islets from stem cells for advanced therapies of diabetes

J Siehler, AK Blöchinger, M Meier… - Nature reviews Drug …, 2021 - nature.com
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

[HTML][HTML] Biomaterials to enhance stem cell transplantation

BN Kharbikar, P Mohindra, TA Desai - Cell Stem Cell, 2022 - cell.com
The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …

[HTML][HTML] Interplay between biomaterials and the immune system: Challenges and opportunities in regenerative medicine

D Salthouse, K Novakovic, CMU Hilkens, AM Ferreira - Acta Biomaterialia, 2023 - Elsevier
The use of biomaterials for tissue engineering and regenerative medicine applications has
increased dramatically over recent years. However, the clinical uptake of a wide variety of …

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

H Newman, YV Shih, S Varghese - Biomaterials, 2021 - Elsevier
Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant
economic and clinical impact. While an inflammatory response upon injury is necessary to …

The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering

D Yang, J Xiao, B Wang, L Li, X Kong, J Liao - Materials Science and …, 2019 - Elsevier
Tissue engineering with scaffolds provides novel prospects for bone/cartilage damage
healing. Previous studies mainly focus on the development of physical/chemical property of …

[HTML][HTML] A magnetic micro-environment in scaffolds for stimulating bone regeneration

C Shuai, W Yang, C He, S Peng, C Gao, Y Yang, F Qi… - Materials & Design, 2020 - Elsevier
In present study, a strategy is presented to construct a magnetic micro-environment in poly-l-
lactide/polyglycolic acid (PLLA/PGA) scaffolds fabricated via selective laser sintering by …

[HTML][HTML] Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment

T Qin, AM Smink, P de Vos - Acta Biomaterialia, 2023 - Elsevier
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …

In vivo printing of nanoenabled scaffolds for the treatment of skeletal muscle injuries

JP Quint, A Mostafavi, Y Endo, A Panayi… - Advanced …, 2021 - Wiley Online Library
Extremity skeletal muscle injuries result in substantial disability. Current treatments fail to
recoup muscle function, but properly designed and implemented tissue engineering and …