Influenza viruses replicate within the nucleus of the host cell. This uncommon RNA virus trait
provides influenza with the advantage of access to the nuclear machinery during replication …

H9N2 avian influenza viruses have become globally widespread in poultry over the last two
decades and represent a genuine threat both to the global poultry industry but also humans …

Abstract The National Institute of Allergy and Infectious Diseases (NIAID) established the
Bioinformatics Resource Center (BRC) program to assist researchers with analyzing the …

Seasonal influenza vaccines offer little protection against pandemic influenza virus strains. It
is difficult to create effective prepandemic vaccines because it is uncertain which influenza …

Highly pathogenic avian influenza A (H5N1) viruses of clade 2.3. 4.4 b underwent an
explosive geographic expansion in 2021 among wild birds and domestic poultry across …

Abstract The UniProt Knowledgebase is a collection of sequences and annotations for over
120 million proteins across all branches of life. Detailed annotations extracted from the …

The degree to which evolution is predictable is a fundamental question in biology. Previous
attempts to predict the evolution of protein sequences have been limited to specific proteins …

Swine influenza A viruses (swIAVs) can play a crucial role in the generation of new human
pandemic viruses. In this study, in-depth passive surveillance comprising nearly 2,500 …

Influenza A viruses (IAVs) are the causative agents of one of the most important viral
respiratory diseases in pigs and humans. Human and swine IAV are prone to interspecies …

Influenza virus can escape most antibodies with single mutations. However, rare antibodies
broadly neutralize many viral strains. It is unclear how easily influenza virus might escape …