Molecular physiology of P2X receptors
RA North - Physiological reviews, 2002 - journals.physiology.org
P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …
Medicinal chemistry of adenosine, P2Y and P2X receptors
KA Jacobson, CE Müller - Neuropharmacology, 2016 - Elsevier
Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles
A Mishra, JP Reynolds, Y Chen, AV Gourine… - Nature …, 2016 - nature.com
Active neurons increase their energy supply by dilating nearby arterioles and capillaries.
This neurovascular coupling underlies blood oxygen level–dependent functional imaging …
This neurovascular coupling underlies blood oxygen level–dependent functional imaging …
Activation and regulation of purinergic P2X receptor channels
Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
Pharmacology of cloned P2X receptors
RA North, A Surprenant - Annual review of pharmacology and …, 2000 - annualreviews.org
There are seven P2X receptor cDNAs currently known. Six homomeric (P2X1, P2X2, P2X3,
P2X4, P2X5, P2X7) and three heteromeric (P2X2/P2X3, P2X4/P2X6, P2X1/P2X5) P2X …
P2X4, P2X5, P2X7) and three heteromeric (P2X2/P2X3, P2X4/P2X6, P2X1/P2X5) P2X …
The Concise Guide to PHARMACOLOGY 2013/14: ion channels
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
[HTML][HTML] Autocrine regulation of T-cell activation by ATP release and P2X7 receptors
L Yip, T Woehrle, R Corriden, M Hirsh, Y Chen… - The FASEB …, 2009 - ncbi.nlm.nih.gov
T-cell activation requires the influx of extracellular calcium, although mechanistic details
regarding such activation are not fully defined. Here, we show that P2X 7 receptors play a …
regarding such activation are not fully defined. Here, we show that P2X 7 receptors play a …
Pharmacology of P2X channels
JR Gever, DA Cockayne, MP Dillon, G Burnstock… - Pflügers Archiv, 2006 - Springer
Significant progress in understanding the pharmacological characteristics and physiological
importance of homomeric and heteromeric P2X channels has been achieved in recent …
importance of homomeric and heteromeric P2X channels has been achieved in recent …
Ligand-gated ion channels: new insights into neurological disorders and ligand recognition
1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat …
RJ Rodrigues, T Almeida, PJ Richardson… - Journal of …, 2005 - Soc Neuroscience
ATP is released in a vesicular manner from nerve terminals mainly at higher stimulation
frequencies. There is a robust expression of ATP (P2) receptors in the brain, but their role is …
frequencies. There is a robust expression of ATP (P2) receptors in the brain, but their role is …