The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (≫
300kb) of DNA that are homogeneous in base composition and are compositionally …

One of the most striking features of mammalian chromosomes is the variation in G+ C
content that occurs over scales of hundreds of kilobases to megabases, the so …

Lampreys are representatives of an ancient vertebrate lineage that diverged from our own∼
500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) …

Although changes in nucleotide sequence affecting the composition and the structure of
proteins are well known, functional changes resulting from nucleotide substitutions cannot …

The GC content of human DNA varies widely across the genome, ranging from 30% to 60%,
and regions of hundreds of kilobases (often referred to as isochores [Bernardi 2000]) may …

This study presents compelling evidence that recombination significantly increases the silent
GC content of a genome in a selectively neutral manner, resulting in a highly significant …

The Cyclostomata consists of the two orders Myxiniformes (hagfishes) and
Petromyzoniformes (lampreys), and its monophyly has been unequivocally supported by …

The causes of the variation between genomes in their guanine (G) and cytosine (C) content
is one of the central issues in evolutionary genomics. The thermal adaptation hypothesis …

The study of correlation structure in the primary sequences of DNA is reviewed. The issues
reviewed include: symmetries among 16 base-base correlation functions; accurate …

Background The third, or wobble, position in a codon provides a high degree of possible
degeneracy and is an elegant fault-tolerance mechanism. Nucleotide biases between …