Understanding how proteins evolve is important, and the order of amino acids being
recruited into the genetic codons was found to be an important factor shaping the amino acid …

Sequence compositions of nucleic acids and proteins have significant impact on gene
expression, RNA stability, translation efficiency, RNA/protein structure and molecular …

The current framework of evolutionary theory postulates that evolution relies on random
mutations generating a diversity of phenotypes on which natural selection acts. This …

In living organisms, biological clocks regulate 24 h (circadian) molecular, physiological, and
behavioral rhythms to maintain homeostasis and synchrony with predictable environmental …

Background As a significant process of post-transcriptional gene expression regulation in
eukaryotic cells, alternative splicing (AS) of exons greatly contributes to the complexity of the …

Cancer-related genes have evolved specific genetic and genomic features to favor tumor
suppression. Previously we reported that tumor suppressor genes (TSGs) acquired high …

Protein-coding nucleic acids exhibit composition and codon biases between sequences
coding for intrinsically disordered regions (IDRs) and those coding for structured regions …

The emergence of new protein-coding genes in a specific lineage or species provides raw
materials for evolutionary adaptations. Until recently, the biology of new genes emerging …

Cancer-related genes are under intense evolutionary pressure. In this study, we conjecture
that X-linked tumor suppressor genes (TSG) are not protected by the Knudson's two-hit …

Tumor suppressor genes (TSGs) exhibit distinct evolutionary features. We speculated that
TSG promoters could have evolved specific features that facilitate their tumor-suppressing …