In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Abstract Extracellular adenosine 5′-triphosphate (ATP) was proposed to be an activity-
dependent signaling molecule that regulates glia–glia and glia–neuron communications …

Neurons of the central nervous system (CNS) are endowed with ATP-sensitive receptors
belonging to the P2X (ligand-gated cationic channels) and P2Y (G protein-coupled …

Norepinephrine exerts an important influence on prefrontal cortical functions. The
physiological effects of β-adrenoceptors (β-ARs) have been examined in other brain …

Glutamate is the main excitatory neurotransmitter of the central nervous system (CNS),
released both from neurons and glial cells. Acting via ionotropic (NMDA, AMPA, kainate) …

Purine and pyrimidine nucleotides are extracellular signaling molecules in the central
nervous system (CNS) leaving the intracellular space of various CNS cell types via …

NMDA receptors in the prefrontal cortex (PFC) play a crucial role in cognitive functions.
Previous research has indicated that angiotensin II (Ang II) affects learning and memory …

In the 1st part of this study, monosynaptic excitatory postsynaptic potentials (EPSPs) in layer
V of the rat prefrontal cortex (PFC) were evoked by electrical stimulation of layer I …

Within the last 15 years, at least eight different G protein-coupled nucleotide receptors, ie,
P2Y receptors, have been characterized by molecular means. While ionotropic P2X …

Abstract The purine adenosine 5′-triphosphate (ATP) and its breakdown products, ADP
and adenosine, act as intercellular messenger molecules throughout the nervous system …