Immunobiology of primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a chronic inflammatory progressive cholestatic liver
disease. Genetic risk factors, presence of autoantibodies, the strong clinical link with …
disease. Genetic risk factors, presence of autoantibodies, the strong clinical link with …
Towards tolerance in liver transplantation
Life-long immunosuppression has always been considered the key in managing liver graft
protection from recipient rejection. However, it is associated with severe adverse effects that …
protection from recipient rejection. However, it is associated with severe adverse effects that …
Autoimmune paneLs as prEdictors of toxicity in patients TReated with immune checkpoint inhibiTors (ALERT)
Background Immune-checkpoint inhibitors (ICI) can lead to immune-related adverse events
(irAEs) in a significant proportion of patients. The mechanisms underlying irAEs …
(irAEs) in a significant proportion of patients. The mechanisms underlying irAEs …
Stem cell therapy for hepatocellular carcinoma and end-stage liver disease
MS Abdellateif, ARN Zekri - Journal of the Egyptian National Cancer …, 2023 - Springer
Hepatocellular carcinoma (HCC) is a major health problem worldwide, especially for
patients who are suffering from end-stage liver disease (ESLD). The ESLD is considered a …
patients who are suffering from end-stage liver disease (ESLD). The ESLD is considered a …
[HTML][HTML] Achievement of operational tolerance in a pediatric liver transplant recipient following successful hematopoietic stem cell transplantation from a different donor
M Algeri, E Velardi, M Spada, F Galaverna… - American Journal of …, 2023 - Elsevier
Hematopoietic stem cell transplantation (HSCT)–based approaches are increasingly
investigated strategies to induce tolerance in recipients of solid allografts. However, in the …
investigated strategies to induce tolerance in recipients of solid allografts. However, in the …
Congenic hematopoietic stem cell transplantation promotes survival of heart allografts in murine models of acute and chronic rejection
H Sadozai, V Rojas-Luengas, K Farrokhi… - Clinical and …, 2023 - academic.oup.com
The ability to induce tolerance would be a major advance in the field of solid organ
transplantation. Here, we investigated whether autologous (congenic) hematopoietic stem …
transplantation. Here, we investigated whether autologous (congenic) hematopoietic stem …
Transplantation immune responses: Biology, challenges, and opportunities using biomaterials
The organs or cells transplantation is well-established in clinics. However, despite the
increasing success rates and the broadening of various transplantation techniques, a key …
increasing success rates and the broadening of various transplantation techniques, a key …
Clinical liver transplant tolerance: Recent topics
M Takatsuki, S Eguchi - Journal of Hepato‐Biliary‐Pancreatic …, 2022 - Wiley Online Library
Background Immunosuppression is essential after organ transplantation to prevent severe
graft injury due to rejection, but in long‐term, transplanted organs are generally accepted …
graft injury due to rejection, but in long‐term, transplanted organs are generally accepted …
Autologous Stem Cell Transplant to Treat Recurrent Primary Sclerosing Cholangitis: Tolerance, But at What Price?
A Griesemer, M Martinez, JC Emond - Transplantation, 2022 - journals.lww.com
In contrast to most liver transplant recipients, patients with autoimmune liver diseases
(AILD), including those with primary sclerosing cholangitis (PSC), are at increased risk for …
(AILD), including those with primary sclerosing cholangitis (PSC), are at increased risk for …