Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
Ketamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …
Epigenetics of autism spectrum disorder: Histone deacetylases
The etiology of autism spectrum disorder (ASD) remains unknown, but gene-environment
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …
Midbrain dopamine neurons arbiter OCD-like behavior
J Xue, D Qian, B Zhang, J Yang, W Li… - Proceedings of the …, 2022 - National Acad Sciences
The neurobiological understanding of obsessive–compulsive disorder (OCD) includes
dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive …
dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive …
MeCP2 is an epigenetic factor that links DNA methylation with brain metabolism
YM Vuu, CT Roberts, M Rastegar - International Journal of Molecular …, 2023 - mdpi.com
DNA methylation, one of the most well-studied epigenetic modifications, is involved in a
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …
Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice
KI Ramírez-Armenta, H Alatriste-León… - …, 2022 - nature.com
Excessive grooming of Sapap3-KO mice has been used as a model of obsessive-
compulsive disorder (OCD). Previous studies suggest that dysregulation of cortico-striatal …
compulsive disorder (OCD). Previous studies suggest that dysregulation of cortico-striatal …
Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice
Obsessive-compulsive disorder (OCD) is a circuit disorder involving corticostriatal
projections, which play a role in motor control. The Sapap3-knockout (KO) mouse is a …
projections, which play a role in motor control. The Sapap3-knockout (KO) mouse is a …
Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action
K Suzuki, JW Kim, E Nosyreva, ET Kavalali… - Cell reports, 2021 - cell.com
Ketamine is a noncompetitive glutamatergic N-methyl-d-aspartate receptor (NMDAR)
antagonist that exerts rapid antidepressant effects. Preclinical studies identify eukaryotic …
antagonist that exerts rapid antidepressant effects. Preclinical studies identify eukaryotic …
Circular RNAs: a novel player in development and disease of the central nervous system
Circular RNAs (circRNAs) own unique capabilities to communicate with nucleic acids and
ribonucleoproteins and are emerging as indispensable compositions of the regulatory …
ribonucleoproteins and are emerging as indispensable compositions of the regulatory …
Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability
Highlights•Mouse models of autism and intellectual disability display circuit-level
alterations.•These deficits link genetic disruptions to behavioral phenotypes.•Phenotypes …
alterations.•These deficits link genetic disruptions to behavioral phenotypes.•Phenotypes …
Developmental lead exposure and prenatal stress result in sex-specific reprograming of adult stress physiology and epigenetic profiles in brain
M Sobolewski, G Varma, B Adams… - Toxicological …, 2018 - academic.oup.com
Developmental exposure to lead (Pb) and prenatal stress (PS) both impair cognition, which
could derive from their joint targeting of the hypothalamic-pituitary-adrenal axis and the brain …
could derive from their joint targeting of the hypothalamic-pituitary-adrenal axis and the brain …