An insight into the arising role of MicroRNAs in hepatocellular carcinoma: future diagnostic and therapeutic approaches

E Koustas, EM Trifylli, P Sarantis… - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) constitutes a frequent highly malignant form of primary liver
cancer and is the third cause of death attributable to malignancy. Despite the improvement …

The role of hepatitis B virus genome variations in HBV-related HCC: effects on host signaling pathways

S Shoraka, SM Hosseinian, A Hasibi… - Frontiers in …, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is a significant global health issue, with a high prevalence
in many regions. There are variations in the etiology of HCC in different regions, but most …

Class a capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation

DB Kum, H Vanrusselt, AA Sanchez, V Taverniti… - Hepatology, 2023 - journals.lww.com
Conclusions: Our study unravels a previously unknown mechanism of action for CAM-As
such as RG7907 in which HBc aggregation induces cell death, resulting in hepatocyte …

Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next?

MX Fu, P Simmonds, M Andersson… - Reviews in Medical …, 2024 - Wiley Online Library
Blood transfusion is a vital procedure, where transfusion‐transmitted infection of hepatitis B
virus (HBV) remains an important issue, especially from blood donors with occult hepatitis B …

Zika virus: Antiviral immune response, inflammation, and cardiotonic steroids as antiviral agents

JM de Sales-Neto, DCM Carvalho… - International …, 2024 - Elsevier
Zika virus (ZIKV) is a mosquito-borne virus first reported from humans in Nigeria in 1954.
The first outbreak occurred in Micronesia followed by an outbreak in French Polynesia and …

Development of therapy based on the exploration of biological events underlying the pathogenetic mechanisms of chronic hepatitis B infection

SMF Akbar, M Al Mahtab, O Yoshida, J Aguilar… - Biomedicines, 2023 - mdpi.com
According to the World Health Organization (WHO), an estimated 296 million people are
chronically infected with hepatitis B virus (HBV). Approximately 15–25% of these people …

Prediction model of ocular metastasis from primary liver cancer: Machine learning‐based development and interpretation study

JQ Sun, SN Wu, ZL Mou, JY Wen, H Wei… - Cancer …, 2023 - Wiley Online Library
Background Ocular metastasis (OM) is a rare metastatic site of primary liver cancer (PLC).
The purpose of this study was to establish a clinical predictive model of OM in PLC patients …

Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond H. pylori and Epstein-Barr Virus

WS Shin, F Xie, B Chen, J Yu, KW Lo, GMK Tse, KF To… - Cancers, 2023 - mdpi.com
Simple Summary The microbiome emerges as a crucial participant in gastric cancer (GC), a
severe cancer burden worldwide. Current understanding has primarily focused on the …

The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma

D Li, D Cao, Y Cui, Y Sun, J Jiang, X Cao - Frontiers in Pharmacology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC), one of the most notorious malignancies globally, has a
high fatality and poor prognosis. Though remarkable breakthroughs have been made in the …

The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype

A Schollmeier, M Basic, M Glitscher, E Hildt - Journal of Virology, 2024 - Am Soc Microbiol
Chronic hepatitis B virus (HBV) infections are strongly associated with liver cirrhosis,
inflammation, and hepatocellular carcinoma. In this context, the viral HBx protein is …