An updated review of autophagy in ischemic stroke: From mechanisms to therapies

X Wang, Y Fang, Q Huang, P Xu, C Lenahan, J Lu… - Experimental …, 2021 - Elsevier
Stroke is a leading cause of mortality and morbidity worldwide. Understanding the
underlying mechanisms is important for developing effective therapies for treating stroke …

Neuroprotective effects of estrogen in CNS injuries: insights from animal models

N Raghava, BC Das, SK Ray - Neuroscience and neuroeconomics, 2017 - Taylor & Francis
Among the estrogens that are biosynthesized in the human body, 17β-estradiol (estradiol or
E2) is the most common and the best estrogen for neuroprotection in animal models of the …

Treadmill exercise exerts neuroprotection and regulates microglial polarization and oxidative stress in a streptozotocin-induced rat model of sporadic Alzheimer's …

Y Lu, Y Dong, D Tucker, R Wang… - Journal of …, 2017 - content.iospress.com
Recent work has suggested that exercise may be beneficial in preventing or ameliorating
symptoms of several neurological disorders, although the mechanism is not entirely …

Neuron-derived estrogen is critical for astrocyte activation and neuroprotection of the ischemic brain

Y Lu, GR Sareddy, J Wang, Q Zhang… - Journal of …, 2020 - Soc Neuroscience
17β-Estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2
is known to be made in neurons in the brain, but the functions of neuron-derived E2 in the …

Low-level laser therapy for beta amyloid toxicity in rat hippocampus

Y Lu, R Wang, Y Dong, D Tucker, N Zhao… - Neurobiology of …, 2017 - Elsevier
Beta amyloid (Aβ) is well accepted to play a central role in the pathogenesis of Alzheimer's
disease (AD). The present work evaluated the therapeutic effects of low-level laser …

Biochanin A alleviates cerebral ischemia/reperfusion injury by suppressing endoplasmic reticulum stress-induced apoptosis and p38MAPK signaling pathway in vivo …

M Guo, S Qu, H Lu, W Wang, ML He, JL Su… - Frontiers in …, 2021 - frontiersin.org
We have previously shown that biochanin A exhibits neuroprotective properties in the
context of cerebral ischemia/reperfusion (I/R) injury. The mechanistic basis for such …

[HTML][HTML] Role of epigenetic regulation in glaucoma

L Feng, C Wang, C Zhang, W Zhang, W Song - Biomedicine & …, 2023 - Elsevier
Glaucoma is the world's leading irreversible blinding eye disease. Lowering intraocular
pressure is currently the only effective clinical treatment. However, there is a lack of long …

Nrf2 pathway and autophagy crosstalk: new insights into therapeutic strategies for ischemic cerebral vascular diseases

Y Hu, Y Luo, Y Zheng - Antioxidants, 2022 - mdpi.com
Cerebrovascular disease is highly prevalent and has a complex etiology and variable
pathophysiological activities. It thus poses a serious threat to human life and health …

Crosstalk between autophagy and cerebral ischemia

Y Sun, Y Zhu, X Zhong, X Chen, J Wang… - Frontiers in …, 2019 - frontiersin.org
With the use of advanced electron microscopy and molecular biology tools, several studies
have shown that autophagy is involved in the development of ischemic stroke. A series of …

Photobiomodulation therapy attenuates hypoxic-ischemic injury in a neonatal rat model

LD Tucker, Y Lu, Y Dong, L Yang, Y Li, N Zhao… - Journal of Molecular …, 2018 - Springer
Photobiomodulation (PBM) has been demonstrated as a neuroprotective strategy, but its
effect on perinatal hypoxic-ischemic encephalopathy is still unknown. The current study was …