Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Non-invasive Vagus nerve stimulation in cerebral stroke: current status and future perspectives

L Li, D Wang, H Pan, L Huang, X Sun, C He… - Frontiers in …, 2022 - frontiersin.org
Stroke poses a serious threat to human health and burdens both society and the healthcare
system. Standard rehabilitative therapies may not be effective in improving functions after …

Vagus nerve stimulation inhibits cortical spreading depression

SP Chen, I Ay, AL De Morais, T Qin, Y Zheng… - Pain, 2016 - journals.lww.com
Vagus nerve stimulation has recently been reported to improve symptoms of migraine.
Cortical spreading depression is the electrophysiological event underlying migraine aura …

Vagus nerve stimulation during rehabilitative training improves forelimb strength following ischemic stroke

N Khodaparast, SA Hays, AM Sloan, DR Hulsey… - Neurobiology of …, 2013 - Elsevier
Upper limb impairment is a common debilitating consequence of ischemic stroke. Physical
rehabilitation after stroke enhances neuroplasticity and improves limb function, but does not …

miR‐210 mediates vagus nerve stimulation‐induced antioxidant stress and anti‐apoptosis reactions following cerebral ischemia/reperfusion injury in rats

Y Jiang, L Li, X Tan, B Liu, Y Zhang… - Journal of …, 2015 - Wiley Online Library
Vagus nerve stimulation (VNS) exerts neuroprotective effects against cerebral
ischemia/reperfusion (I/R) injury and modulates redox status, potentially through the activity …

Vagus nerve stimulation during rehabilitative training improves forelimb recovery after chronic ischemic stroke in rats

N Khodaparast, MP Kilgard… - … and neural repair, 2016 - journals.sagepub.com
Background and objective. Stroke is a leading cause of long-term disability. Currently, there
are no consistently effective rehabilitative treatments for chronic stroke patients. Our recent …

Vagus nerve stimulation attenuates cerebral ischemia and reperfusion injury via endogenous cholinergic pathway in rat

Y Jiang, L Li, B Liu, Y Zhang, Q Chen, C Li - PloS one, 2014 - journals.plos.org
Inflammation and apoptosis play critical roles in the acute progression of ischemic injury
pathology. Emerging evidence indicates that vagus nerve stimulation (VNS) following focal …

PPAR‐γ Mediates Ta‐VNS‐Induced Angiogenesis and Subsequent Functional Recovery after Experimental Stroke in Rats

J Li, K Zhang, Q Zhang, X Zhou, L Wen… - BioMed Research …, 2020 - Wiley Online Library
Background. Neoangiogenesis after cerebral ischemia in mammals is insufficient to restore
neurological function, illustrating the need to design better strategies for improving …

Vagus nerve stimulation in ischemic stroke: old wine in a new bottle

PY Cai, A Bodhit, R Derequito, S Ansari… - Frontiers in …, 2014 - frontiersin.org
Vagus nerve stimulation (VNS) is currently Food and Drug Administration-approved for
treatment of both medically refractory partial-onset seizures and severe, recurrent refractory …

Vagus nerve stimulation during rehabilitative training enhances recovery of forelimb function after ischemic stroke in aged rats

SA Hays, A Ruiz, T Bethea, N Khodaparast… - Neurobiology of …, 2016 - Elsevier
Advanced age is associated with a higher incidence of stroke and worse functional
outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as …