4-Acylhydrazone-5-pyrazolones and their zinc (II) metal complexes: synthesis, characterization, crystal feature and antimalarial activity
Abstract Two novel 4-acylhydrazone-5-pyrazolones (L 1=(Z)-N'-((4-chlorophenyl)(3-methyl-5-
oxo-1-(p-tolyl)-4, 5-dihydro-1H-pyrazol-4-yl) methylene) benzohydrazide and L 2=(Z)-N'-((4 …
oxo-1-(p-tolyl)-4, 5-dihydro-1H-pyrazol-4-yl) methylene) benzohydrazide and L 2=(Z)-N'-((4 …
Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo
L Bounaadja, M Schmitt, S Albrecht, E Mouray… - Malaria Journal, 2017 - Springer
Background Plasmodium falciparum M1 family aminopeptidase is currently considered as a
promising target for anti-malarial chemotherapy. Several series of inhibitors developed by …
promising target for anti-malarial chemotherapy. Several series of inhibitors developed by …
Structural characterization of plasmodial aminopeptidase: a combined molecular docking and QSAR-based in silico approaches
F Wang, X Hu, B Zhou - Molecular Diversity, 2019 - Springer
Abstract Aminopeptidase M1 (PfAM1) is one of the key enzymes involved in the
development of new antimalarials. To accelerate the discovery of inhibitors with selective …
development of new antimalarials. To accelerate the discovery of inhibitors with selective …
[PDF][PDF] Characterising the aminopeptidases of Plasmodium falciparum as potential drug targets
R Edgar - 2023 - dro.deakin.edu.au
This study investigated the two aminopeptidases PfA-M1 and PfA-M17 from the human
malaria species Plasmodium falciparum. It found them to be potential new targets for malaria …
malaria species Plasmodium falciparum. It found them to be potential new targets for malaria …
[PDF][PDF] Characterising the M1 and M17 aminopeptidases in Plasmodium falciparum
R Edgar - 2018 - dro.deakin.edu.au
The enzymes M1 and M17 are used by the malarial parasite Plasmodium falciparum to
digest the contents of the human red blood cells during infection. Here, work to characterise …
digest the contents of the human red blood cells during infection. Here, work to characterise …