Chemokines and chemokine receptors: new targets for cancer immunotherapy

V Mollica Poeta, M Massara, A Capucetti… - Frontiers in …, 2019 - frontiersin.org
Immunotherapy is a clinically validated treatment for many cancers to boost the immune
system against tumor growth and dissemination. Several strategies are used to harness …

[HTML][HTML] Immunosuppression in glioblastoma: current understanding and therapeutic implications

BT Himes, PA Geiger, K Ayasoufi, AG Bhargav… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma (GBM) is the most common primary brain tumor in adults an carries and carries
a terrible prognosis. The current regiment of surgical resection, radiation, and chemotherapy …

Myeloid cells in glioblastoma microenvironment

A De Leo, A Ugolini, F Veglia - Cells, 2020 - mdpi.com
Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …

Prognostic values of systemic inflammatory immunological markers in glioblastoma: A systematic review and meta-analysis

P Jarmuzek, K Kozlowska, P Defort, M Kot… - Cancers, 2023 - mdpi.com
Simple Summary The authors report the most up-to-date review and a thorough meta-
analysis of inflammatory, immunological markers such as neutrophil-to-lymphocyte ratio …

The role of selected chemokines and their receptors in the development of gliomas

M Groblewska, A Litman-Zawadzka… - International journal of …, 2020 - mdpi.com
Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the
most frequent type, with glioblastoma multiforme (GBM) characterized with the worst …

Role of inflammatory mediators, macrophages, and neutrophils in glioma maintenance and progression: mechanistic understanding and potential therapeutic …

AS Basheer, F Abas, I Othman, R Naidu - Cancers, 2021 - mdpi.com
Simple Summary The tumor microenvironment is a complex network comprised of
neoplastic and a variety of immune cells, proteins, and inflammatory mediators. Previous …

Imaging biomarkers for clinical applications in neuro-oncology: current status and future perspectives

FY Chiu, Y Yen - Biomarker Research, 2023 - Springer
Biomarker discovery and development are popular for detecting the subtle diseases.
However, biomarkers are needed to be validated and approved, and even fewer are ever …

Matrix remodeling-associated protein 8 as a novel indicator contributing to glioma immune response by regulating ferroptosis

Z Xu, X Chen, L Song, F Yuan, Y Yan - Frontiers in immunology, 2022 - frontiersin.org
Glioma is a highly malignant brain tumor with a poor survival rate. Novel biomarkers that act
as prompt indicators of glioma are urgently needed. In this study, we identified and validated …

Role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance

S Khan, S Mittal, K McGee, KD Alfaro-Munoz… - International journal of …, 2020 - mdpi.com
Recent efforts in brain tumor research have been directed towards the modulation of the
immune system for therapeutic interventions. Several human cancers, including gliomas, are …

Friends with benefits: chemokines, glioblastoma-associated microglia/macrophages, and tumor microenvironment

E Codrici, ID Popescu, C Tanase, AM Enciu - International journal of …, 2022 - mdpi.com
Glioma is the most common primary intracranial tumor and has the greatest prevalence of all
brain tumors. Treatment resistance and tumor recurrence in GBM are mostly explained by …