Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …

Conspectus Nanoparticles are widely used in various biomedical applications as drug
delivery carriers, imaging probes, single-molecule tracking/detection probes, artificial …

Biomacromolecules are highly promising therapeutic modalities to treat various diseases.
However, they suffer from poor cellular membrane permeability, limiting their access to …

Designing a therapeutic modality that will reach a certain organ, tissue, or cell type is crucial
for both the therapeutic efficiency and to limit off-target adverse effects. Nanoparticles …

Lipid nanoparticles (LNPs), a nonviral nucleic acid delivery system, have shown vast
potential for vaccine development and disease treatment. LNPs assist mRNA to cross …

COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public
health measures remain the most effective protection strategy at this stage, when the peak …

Polyelectrolyte capsules (PCs) are a promising tool for anticancer drug delivery and tumor
targeting. Surface functionalization of PCs with antibodies is widely used for providing their …

The antimicrobial and cytotoxic effects of zinc oxide nanomaterials are popularly thought to
be occurring due to zinc ion leaching, but the exact mechanism of cytotoxicity is …

Nonendocytic cell uptake of nanomaterials is challenging, which requires specific surface
chemistry and smaller particle size. Earlier works have shown that an arginine-terminated …

Intracellular delivery of therapeutic biomacromolecules is often challenged by the poor
transmembrane and limited endosomal escape. Here, we establish a combinatorial library …