Polysorbates (PS) are widely used as a stabilizer in biopharmaceutical products. Industry
practices on various aspects of PS are presented in this part 1 survey report based on a …

Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty
acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug …

Therapeutically relevant proteins naturally adsorb to interfaces, causing aggregation which
in turn potentially leads to numerous adverse consequences such as loss of activity or …

Purpose Alzheimer's disease (AD) is a growing concern in the modern society. The current
drugs approved by FDA are not very promising. Rhynchophylline (RIN) is a major active …

Abstract Di-(2-ethylhexyl) phthalate (DEHP), an endocrine-disrupting chemical (EDC)
commonly used as a plasticizer, is responsible for widespread environmental pollution …

A liquid chromatography-mass spectrometry (LC–MS) method was developed to provide a
fingerprint of polysorbate 80 (PS80) subspecies that enables identification of PS80 …

Polysorbate 80 (PS80) is widely used as an excipient in vaccines and biopharmaceuticals.
The oxidized species of PS80 have raised concern because of their potential to compromise …

Abstract Polysorbate‐80 (PS80) and histidine are common excipients in vaccine and
therapeutic protein formulation. A simple quantitative NMR method to measure both PS80 …

Rationale Polysorbate 80 (PS80) is an amphipathic, nonionic surfactant commonly used in
pharmaceutical protein formulations and is composed of fatty acid (FA) esters of …

The commercially available Polysorbate 80 (PS-80) is a highly heterogeneous product. It is
a complex and structurally diverse mixture consisting of polymeric species containing …