Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene
therapy owing to its minimal pathogenicity and ability to establish long-term gene expression …

Gene therapy is the process of introducing foreign genomic materials into host cells to elicit
a therapeutic benefit. Although initially the main focus of gene therapy was on special …

Extensively characterized, modified, and employed for a variety of purposes, adenovirus
(Ad) vectors are generally regarded as having great potential by many applied virologists …

To achieve therapeutic success, transfer vehicles for gene therapy must be capable of
transducing target cells while avoiding impact on non-target cells. Despite the high …

In the late 1970s, it was predicted that gene therapy would be applied to humans within a
decade. However, despite some success, gene therapy has still not become a routine …

Last-generation adenovirus vectors, also called helper-dependent or gutless adenovirus,
are very attractive for gene therapy because the associated in vivo immune response is …

Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of
therapeutic and vaccine purposes during last two decades. However, the presence of …

Fenestrae allow the passage of gene transfer vectors from the sinusoidal lumen to the
surface of hepatocytes. We have previously shown that the diameter of fenestrae correlates …

The chemical modification of adenovirus (Ad) gene transfer vectors with synthetic polymers
is a promising strategy for overcoming typical in vivo hurdles associated with Ad-mediated …

An adenoviral (AdV)-based vector system is a promising platform for vaccine development
and gene therapy applications. Administration of an AdV vector elicits robust innate …