Functional synthetic probes for selective targeting and multi-analyte detection and imaging
In contrast to the classical design of a probe with one binding site to target one specific
analyte, probes with multiple interaction sites or, alternatively, with single sites promoting …
analyte, probes with multiple interaction sites or, alternatively, with single sites promoting …
The origin of NMDA receptor hypofunction in schizophrenia
K Nakazawa, K Sapkota - Pharmacology & therapeutics, 2020 - Elsevier
Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …
Redox signaling mediated by thioredoxin and glutathione systems in the central nervous system
Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Nitric oxide function in plant biology: a redox cue in deconvolution
Nitric oxide (NO), a gaseous, redox‐active small molecule, is gradually becoming
established as a central regulator of growth, development, immunity and environmental …
established as a central regulator of growth, development, immunity and environmental …
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
GE Hardingham, KQ Do - Nature Reviews Neuroscience, 2016 - nature.com
Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
Selective neuronal vulnerability to oxidative stress in the brain
X Wang, EK Michaelis - Frontiers in aging neuroscience, 2010 - frontiersin.org
Oxidative stress (OS), caused by the imbalance between the generation and detoxification of
reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging …
reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging …
The diverse functions of GAPDH: views from different subcellular compartments
C Tristan, N Shahani, TW Sedlak, A Sawa - Cellular signalling, 2011 - Elsevier
Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …
Metal dyshomeostasis and oxidative stress in Alzheimer's disease
MA Greenough, J Camakaris, AI Bush - Neurochemistry international, 2013 - Elsevier
Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …
Protein S-nitrosylation: purview and parameters
S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain
of cysteine, has emerged as an important mechanism for dynamic, post-translational …
of cysteine, has emerged as an important mechanism for dynamic, post-translational …