In recent years, there has been a paradigm shift with regards to ageing, challenging its
traditional perception as an inevitable and natural process. Researchers have collectively …

Tumorigenesis is driven by the gain-of-function mutation or overexpression of oncogenes,
as well as by the inactivation of oncosuppresssive (tumor suppressor) genes due to their …

Abstract D-β-hydroxybutyrate, BHB, has been previously proposed as an anti-senescent
agent in vitro and in vivo in several tissues including vascular smooth muscle. Moreover …

Purpose Liver-expressed antimicrobial peptide 2 (LEAP-2) has been recently identified as
the endogenous non-competitive allosteric antagonist of the growth hormone secretagogue …

This master thesis delves into the crucial role of lamin A, an important intermediate type V
protein for cellular structural integrity with influence on gene expression regulation and …

Lipodystrophy syndromes are rare diseases characterized by low levels and an abnormal
distribution of adipose tissue, caused by diverse genetic or acquired causes. These …