This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in
animals and humans, but the mechanism of this effect is unknown. It has been hypothesized …

Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …

The cellular and molecular mechanisms that enable us to sense cold are not well
understood. Insights into this process have come from the use of pharmacological agents …

Mammals detect temperature with specialized neurons in the peripheral nervous system.
Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class …

Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Mechanosensitive ion channels underlie neuronal responses to physical forces in the
sensation of touch, hearing, and other mechanical stimuli. The fundamental basis of force …

Sensory nerve fibres can detect changes in temperature over a remarkably wide range, a
process that has been proposed to involve direct activation of thermosensitive excitatory …

Ultrasound modulates the electrical activity of excitable cells and offers advantages over
other neuromodulatory techniques; for example, it can be noninvasively transmitted through …