The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial
activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator …

Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and
reside in various tissues, including bone marrow and adipose tissue. The differentiation …

Metastasis is the leading cause of cancer-related deaths; metastatic lesions develop from
disseminated cancer cells (DCCs) that can remain dormant. Metastasis-initiating cells are …

The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-
subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

Abstract β-Catenin-dependent canonical Wnt signaling plays an important role in bone
metabolism by controlling differentiation of bone-forming osteoblasts and bone-resorbing …

Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐
spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form …

Summary The Disrupted in Schizophrenia 1 (DISC1) gene is disrupted by a balanced
chromosomal translocation (1; 11)(q42; q14. 3) in a Scottish family with a high incidence of …

Wnt signaling regulates embryonic pattern formation and morphogenesis of most organs.
Aberrations of regulation of Wnt signaling may lead to cancer. Here, we have used …

More than 20 years ago, the oncogenicity of a Wnt ligand was revealed in a series of
experiments originating with random proviral integration in mice. The significance of Wnt …