▪ Abstract Comparative modeling predicts the three-dimensional structure of a given protein
sequence (target) based primarily on its alignment to one or more proteins of known …

Since the process of building and refining a model of a biomacromolecule based on
crystallographic data is subjective, quality-control techniques are required to assess the …

We present a series of databanks (http://swift. cmbi. ru. nl/gv/facilities/) that hold information
that is computationally derived from Protein Data Bank (PDB) entries and that might …

Abstract The Protein Data Bank (PDB; http://www. rcsb. org/pdb/) is the single worldwide
archive of structural data of biological macromolecules. This paper describes the goals of …

Abstract The Protein Data Bank (PDB) is the world-wide repository of macromolecular
structure information. We present a series of databases that run parallel to the PDB. Each …

One of the conclusions drawn at the CASP4 meeting in Asilomar was that applying various
force fields during refinement of template‐based models tends to move predictions in the …

Today's energy functions are not able yet to distinguish reliably between correct and almost
correct protein models. Improving these near‐native models is currently a major bottle‐neck …

Motivation Statistical methods that compare observed and expected distributions of
experimental observables provide powerful tools for the quality control of protein structures …

Protein aggregation remains a major area of focus in the production of monoclonal
antibodies. Improving the intrinsic properties of antibodies can improve manufacturability …

MOTIVATION: Homology modeling is rapidly becoming the method of choice for obtaining
three-dimensional coordinates for proteins because genome projects produce sequences at …