Interplay between circadian clock and cancer: new frontiers for cancer treatment

G Sulli, MTY Lam, S Panda - Trends in cancer, 2019 - cell.com
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

Roles of circadian clocks in cancer pathogenesis and treatment

Y Lee - Experimental & molecular medicine, 2021 - nature.com
Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h
rhythms in cellular and bodily functions across nearly all living species. These internal clock …

Medicine in the fourth dimension

CR Cederroth, U Albrecht, J Bass, SA Brown… - Cell metabolism, 2019 - cell.com
The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation

I Aiello, MLM Fedele, F Román, L Marpegan… - Science …, 2020 - science.org
Circadian disruption negatively affects physiology, posing a global health threat that
manifests in proliferative, metabolic, and immune diseases, among others. Because outputs …

Circadian rhythms, disease and chronotherapy

Y Lee, JM Field, A Sehgal - Journal of biological rhythms, 2021 - journals.sagepub.com
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

The genetics of circadian rhythms, sleep and health

A Jagannath, L Taylor, Z Wakaf… - Human molecular …, 2017 - academic.oup.com
Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …

Interconnection between circadian clocks and thyroid function

K Ikegami, S Refetoff, E Van Cauter… - Nature Reviews …, 2019 - nature.com
Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by
transcription–translation feedback loops of specific genes, which are referred to as 'circadian …

Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models

M Das, LG Ellies, D Kumar, C Sauceda, A Oberg… - Nature …, 2021 - nature.com
Accumulating evidence indicates that obesity with its associated metabolic dysregulation,
including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of …

[HTML][HTML] Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease

J Martel, SH Chang, G Chevalier, DM Ojcius… - biomedical journal, 2023 - Elsevier
Living organisms have evolved within the natural electromagnetic fields (EMFs) of the earth
which comprise the global atmospheric electrical circuit, Schumann resonances (SRs) and …

Circadian clock, cell division, and cancer: from molecules to organism

A Shostak - International journal of molecular sciences, 2017 - mdpi.com
As a response to environmental changes driven by the Earth's axial rotation, most organisms
evolved an internal biological timer—the so called circadian clock—which regulates …