Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

A growing number of studies now suggest that the cellular mechanisms which normally
participate in signaling in the central nervous system (CNS) can be transformed by disease …

The human brain depends on its blood supply for a continuous supply of oxygen and
glucose. Irreversible brain damage occurs if blood flow is reduced below about 10 ml/100 g …

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Recent studies suggest that excitatory amino acids (EAAs) have a wide variety of
physiological and pathophysiological roles during central nervous system (CNS) …

We have demonstrated previously that mild intraischemic hypothermia confers a marked
protective effect on the final histopathological outcome. The present study was carried out to …

Using a controlled cortical impact model of traumatic brain injury (TBI) coupled with tissue
microdialysis, interstitial concentrations of aspartate and glutamate (together with serine and …

We have previously described a marked attenuation of postischemic striatal neuronal death
by prior substantia nigra (SN) lesioning. The present study was carried out to evaluate …

WE have recently shown that long-term, but not acute, treatment with lithium robustly
protects cultured CNS neurons against excitotoxicity mediated by NMDA receptors. Since …