The first case reports of amyotrophic lateral sclerosis (ALS) date back to Charles Bell in
1824. 1 Although a variety of other clinical descriptions followed throughout the 1850s, 2–4 …

Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content
has important implications for understanding brain plasticity and neurodegenerative …

Throughout early neurodevelopment, myelination helps provide the foundation for brain
connectivity and supports the emergence of cognitive and behavioral functioning. Early life …

Myelin is important for the normal development and healthy function of the nervous system.
Recent developments in MRI acquisition and tissue modeling aim to provide a better …

Infancy and early childhood are periods of rapid brain development, during which brain
structure and function mature alongside evolving cognitive ability. An important …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …

Objective The neurodegenerative disease, amyotrophic lateral sclerosis (ALS), is a
heterogeneous clinical syndrome involving multiple molecular pathways. The development …

The normal myelination of neuronal axons is essential to neurodevelopment, allowing fast
inter‐neuronal communication. The most dynamic period of myelination occurs in the first …

Objective Diffusion tensor imaging (DTI) is sensitive to white matter tract pathology. A core
signature involving the corticospinal tracts (CST s) has been identified in amyotrophic lateral …

Post-mortem studies have shown the maturation of the brain's myelinated white matter,
crucial for efficient and coordinated brain communication, follows a nonlinear spatio …