A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge

T Winkler, FA Sass, GN Duda… - Bone & joint …, 2018 - boneandjoint.org.uk
Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment

VDL Putra, KA Kilian, ML Knothe Tate - Communications Biology, 2023 - nature.com
Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

Biopolymer-based functional composites for medical applications

SB Park, E Lih, KS Park, YK Joung, DK Han - Progress in Polymer Science, 2017 - Elsevier
Over the last decade, numerous biopolymers have received more attention in medical
applications involving novel biomaterials because of their biocompatibility, biodegradability …

Role of mesenchymal stem cells in bone regenerative medicine: what is the evidence?

A Oryan, A Kamali, A Moshiri… - Cells Tissues …, 2017 - karger.com
Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

The evolution of polystyrene as a cell culture material

MJ Lerman, J Lembong, S Muramoto… - … Engineering Part B …, 2018 - liebertpub.com
Polystyrene (PS) has brought in vitro cell culture from its humble beginnings to the modern
era, propelling dozens of research fields along the way. This review discusses the …

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

W Lee, HA Leddy, Y Chen, SH Lee… - Proceedings of the …, 2014 - National Acad Sciences
Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …

Mechanism of regulation of stem cell differentiation by matrix stiffness

H Lv, L Li, M Sun, Y Zhang, L Chen, Y Rong… - Stem cell research & …, 2015 - Springer
Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

[HTML][HTML] Adipose tissue: physiology to metabolic dysfunction

AJ Richard, U White, CM Elks, JM Stephens - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Collagen promotes higher adhesion, survival and proliferation of mesenchymal stem cells

C Somaiah, A Kumar, D Mawrie, A Sharma, SD Patil… - PloS one, 2015 - journals.plos.org
Mesenchymal stem cells (MSC) can differentiate into several cell types and are desirable
candidates for cell therapy and tissue engineering. However, due to poor cell survival …

Articular fibrocartilage-targeted therapy by microtubule stabilization

J Li, H Jiang, Z Lv, Z Sun, C Cheng, G Tan, M Wang… - Science …, 2022 - science.org
The fibrocartilage presented on the joint surface was caused by cartilage injury or
degeneration. There is still a lack of effective strategies for fibrocartilage. Here, we …