[HTML][HTML] Human health risk assessment for contaminated sites: A retrospective review

S Zhang, Y Han, J Peng, Y Chen, L Zhan, J Li - Environment International, 2023 - Elsevier
Soil contamination is a serious global hazard as contaminants can migrate to the human
body through the soil, water, air, and food, threatening human health. Human Health Risk …

A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement

TJ Woodruff, SDG Rayasam, DA Axelrad… - Environmental …, 2023 - Springer
The manufacture and production of industrial chemicals continues to increase, with
hundreds of thousands of chemicals and chemical mixtures used worldwide, leading to …

Exposure and toxicity characterization of chemical emissions and chemicals in products: global recommendations and implementation in USEtox

P Fantke, WA Chiu, L Aylward, R Judson… - The international journal …, 2021 - Springer
Purpose Reducing chemical pressure on human and environmental health is an integral
part of the global sustainability agenda. Guidelines for deriving globally applicable, life cycle …

[HTML][HTML] Preschool children health impacts from indoor exposure to PM2. 5 and metals

A Mainka, P Fantke - Environment international, 2022 - Elsevier
To better understand the relation between children health and indoor air quality, we
measured the concentrations of fine particulate matter (PM 2.5) and 11 metals (arsenic …

Toxic Substances Control Act (TSCA) implementation: how the amended law has failed to protect vulnerable populations from toxic chemicals in the United States

SDG Rayasam, PD Koman, DA Axelrad… - … science & technology, 2022 - ACS Publications
Exposures to industrial chemicals are widespread and can increase the risk of adverse
health effects such as cancer, developmental disorders, respiratory effects, diabetes, and …

Risk-based chemical ranking and generating a prioritized human exposome database

F Zhao, L Li, Y Chen, Y Huang… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Due to the ubiquitous use of chemicals in modern society, humans are
increasingly exposed to thousands of chemicals that contribute to a major portion of the …

Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment

JR Varshavsky, SDG Rayasam, JB Sass… - Environmental …, 2023 - Springer
A key element of risk assessment is accounting for the full range of variability in response to
environmental exposures. Default dose-response methods typically assume a 10-fold …

Occurrence and health risks of organic micro-pollutants and metals in groundwater of Chinese rural areas

X Li, T Tian, X Shang, R Zhang, H Xie… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Groundwater is a main drinking-water source for Chinese rural residents. The
overall pollution status of organic micropollutants (OMPs) and metals in the groundwater …

Goods that are good enough: Introducing an absolute sustainability perspective for managing chemicals in consumer products

P Fantke, N Illner - Current Opinion in Green and Sustainable Chemistry, 2019 - Elsevier
While many products become more sustainable, overall pressure from emissions and
exposure to chemicals in products on human and environmental health increases, driven by …

Variability in in vivo studies: Defining the upper limit of performance for predictions of systemic effect levels

LL Pham, SM Watford, P Pradeep, MT Martin… - Computational …, 2020 - Elsevier
New approach methodologies (NAMs) for chemical hazard assessment are often evaluated
via comparison to animal studies; however, variability in animal study data limits NAM …