Biological activity of ionic liquids and their application in pharmaceutics and medicine

KS Egorova, EG Gordeev, VP Ananikov - Chemical reviews, 2017 - ACS Publications
Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

“Solvent-in-salt” systems for design of new materials in chemistry, biology and energy research

VA Azov, KS Egorova, MM Seitkalieva… - Chemical society …, 2018 - pubs.rsc.org
Inorganic and organic “solvent-in-salt”(SIS) systems have been known for decades but have
attracted significant attention only recently. Molten salt hydrates/solvates have been …

Do Ionic Liquids Exhibit the Required Characteristics to Dissolve, Extract, Stabilize, and Purify Proteins? Past-Present-Future Assessment

P Bharmoria, AA Tietze, D Mondal, TS Kang… - Chemical …, 2024 - ACS Publications
Proteins are highly labile molecules, thus requiring the presence of appropriate solvents and
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …

[HTML][HTML] Proteins in ionic liquids: Reactions, applications, and futures

A Schindl, ML Hagen, S Muzammal… - Frontiers in …, 2019 - frontiersin.org
Biopolymer processing and handling is greatly facilitated by the use of ionic liquids, given
the increased solubility, and in some cases, structural stability imparted to these molecules …

Computer-aided engineering of lipases solvent tolerance enhanced their applications in sugar esters synthesis: State of the art

Y Qi, M Chen, T Jin, W Chong, Z Zhang, B Nian… - Trends in Food Science & …, 2024 - Elsevier
Abstract Background Sugar esters (SEs) are non-ionic amphiphilic surfactants that possess
excellent emulsifying properties, and consequently have potential applications in the food …

Biocompatibility of ionic liquids towards protein stability: A comprehensive overview on the current understanding and their implications

A Kumar, M Bisht, P Venkatesu - International journal of biological …, 2017 - Elsevier
Over the past years since the discovery of ionic liquids (ILs), there is an increased demand
to consider ILs as novel biocompatible co-solvents for proteins. Due to their tunable physical …

[HTML][HTML] Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems

LK Harada, JFB Pereira, WF Campos… - Journal of the Brazilian …, 2018 - SciELO Brasil
Over the last few years, researchers have started to explore a particular class of compounds
defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a …

The effect of imidazolium cations on the structure and activity of the Candida antarctica Lipase B enzyme in ionic liquids

HS Kim, D Eom, YM Koo, YG Yingling - Physical Chemistry Chemical …, 2016 - pubs.rsc.org
In order to understand how cations affect the structural changes and enzyme activity of
Lipase B from Candida antarctica, we performed all-atom molecular dynamics simulations of …

Kinetics and mechanism of ionic-liquid induced protein unfolding: application to the model protein HP35

HJ Tung, J Pfaendtner - Molecular Systems Design & Engineering, 2016 - pubs.rsc.org
We demonstrate an approach to quantify protein unfolding times using molecular simulation
in a greatly accelerated manner compared to standard MD simulations, showing up to 400 …

Structural stability of insulin aspart in aqueous cholinium aminoate ionic liquids based on molecular dynamics simulation studies

V Sundaram, RN Ramanan, M Selvaraj… - Journal of Molecular …, 2021 - Elsevier
Conformational stability is an important criterion for proteins applied in food,
biopharmaceutical, and biochemical industries. The fluctuations of temperature during …