Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

We characterized the world's second case with ascertained extreme resilience to autosomal
dominant Alzheimer's disease (ADAD). Side-by-side comparisons of this male case and the …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

A recent case report described an individual who was a homozygous carrier of the APOE3
Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer's Disease …

Abstract Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset
Alzheimer's disease (LOAD), leading to earlier age of clinical onset and exacerbating …

Dementia, a prevalent condition among older individuals, has profound societal
implications. Extensive research has resulted in no cure for what is perceived as the most …

Background Variants in APOE and PSEN1 (encoding apolipoprotein E and presenilin 1,
respectively) alter the risk of Alzheimer's disease. We previously reported a delay of …

Tauopathies are a heterogeneous group of neurodegenerative disorders that are
characterised by the aggregation of the microtubule-associated protein tau into filamentous …