Autophagy is a highly conserved catabolic pathway that is precisely regulated and plays a
significant role in maintaining cellular metabolic balance and intracellular homeostasis …

All-trans-retinoic acid (ATRA)-based differentiation therapy of acute promyelocytic leukemia
(APL) represents one of the most clinically effective examples of precision medicine and the …

Acquisition of drug resistance remains a chief impediment to successful cancer therapy, and
we previously described a transient drug-tolerant cancer cell population (DTPs) whose …

Acute myeloid leukemia (AML), which is common in the elderly population, accounts for poor
long-term survival with a high possibility of relapse. The associated lack of currently …

Since protein activity is often regulated by posttranslational modifications, the qualitative and
quantitative analysis of modification sites is critical for understanding the regulation of …

Abstract Background Information Coiled‐coil domain‐containing protein‐124 (Ccdc124) is a
conserved eukaryotic ribosome‐associated RNA‐binding protein which is involved in …

Histone H3 lysine 9 methylation (H3K9me), which is written by the Euchromatic Histone
Lysine Methyltransferases EHMT1 and EHMT2 and read by the heterochromatin protein 1 …

The most common acute hematological malignancy in adults is acute myeloid leukaemia
(AML), accounting for more than 80% of cases in patients over 60 years of age [1]. AML is …

Colorectal cancer (CRC) remains one of the leading gastrointestinal malignancies
worldwide. Development of effective therapeutics for patients diagnosed with CRC remains …

La leucemia mieloide aguda (LMA) es una enfermedad que se caracteriza por la
proliferación excesiva de mieloblastos inmaduros en la médula ósea. Esta enfermedad …