Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Many important interactions between bacterial pathogens and their hosts are highly specific
binding events that involve host or pathogen carbohydrate structures (glycans). Glycan …

Streptococcus pneumoniae is an important pathogen causing invasive diseases such as
sepsis, meningitis, and pneumonia. The burden of disease is highest in the youngest and …

Infectious disease is the major cause of morbidity and mortality in developing countries,
particularly in children. Increasing evidence suggests that protein-calorie malnutrition is the …

The cell wall envelope of gram-positive bacteria is a macromolecular, exoskeletal organelle
that is assembled and turned over at designated sites. The cell wall also functions as a …

Through their specific interactions with proteins, cellular glycans play key roles in a wide
range of physiological and pathological processes. One of the main goals of research in the …

The overall goal for this review is to summarize the current body of knowledge about the
structure and function of major known antigens of Streptococcus pneumoniae, a major gram …

Although pneumococcal conjugate vaccines are close to being licensed, a more profound
knowledge of the virulence factors responsible for the morbidity and mortality caused by …

The cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins that
are produced by more than 20 species from the genera Clostridium, Streptococcus, Listeria …