Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …

Several epidemiological and experimental studies have demonstrated that many human
diseases are not only caused by specific genetic and environmental factors but also by gene …

Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …

Colorectal cancer (CRC) is a complex disease that develops as a consequence of both
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …

It is speculated that genetic variants are associated with differential responses to nutrients
(known as gene–diet interactions) and that these variations may be linked to different cancer …

Objective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide.
Defining critical research gaps (RG), their prioritisation and resolution, could improve patient …

Background Evidence is lacking on the impact of alcohol consumption on colorectal cancer
(CRC) risk (overall and by age at diagnosis) by polygenic risk score (PRS) levels, and it is …

The cause of colorectal cancer (CRC) is multifactorial, involving both genetic variants and
environmental risk factors. We systematically searched the MEDLINE, EMBASE, China …

Colorectal cancer (CRC) is a disease involving a variety of genetic and environmental
factors. Sirtuin-3 (Sirt3) is expressed at a low level in cancer tissues of CRC, but it is unclear …

The role of folate, a water-soluble B-vitamin, in cancer development and progression
remains highly controversial. The crux of the hotly debated issue is whether folic acid (the …