Mechanisms of spermidine-induced autophagy and geroprotection

SJ Hofer, AK Simon, M Bergmann, T Eisenberg… - Nature aging, 2022 - nature.com
Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

Role of eIF5A in mitochondrial function

M Barba-Aliaga, P Alepuz - International journal of molecular sciences, 2022 - mdpi.com
The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein
that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or …

Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging

Y Zhang, J Bai, Z Cui, Y Li, Q Gao, Y Miao, B Xiong - Nature Aging, 2023 - nature.com
Advanced age is a primary risk factor for female infertility due to reduced ovarian reserve
and declining oocyte quality. However, as an important contributing factor, the role of …

Protective effects of mitophagy enhancers against amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer disease

S Kshirsagar, N Sawant, H Morton… - Human molecular …, 2022 - academic.oup.com
The purpose of our study is to determine the protective effects of mitophagy enhancers
against mutant APP and amyloid beta (Aβ)-induced mitochondrial and synaptic toxicities in …

Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression

T Zhang, W Fu, H Zhang, J Li, B Xing, Y Cai… - Nature Cell …, 2024 - nature.com
It has been established that N-acetyltransferase (murine NAT1 (mNAT1) and human NAT2
(hNAT2)) mediates insulin sensitivity in type 2 diabetes. Here we show that mNAT1 …

The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles

M Tauc, M Cougnon, R Carcy, N Melis, T Hauet… - Cell & Bioscience, 2021 - Springer
Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor
5A (eIF5A) has been studied principally in relation to the development and progression of …

Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models

S Inamdar, T Tylek, A Thumsi, AP Suresh… - Biomaterials, 2023 - Elsevier
Although different metabolic pathways have been associated with distinct macrophage
phenotypes, the field of utilizing metabolites to modulate macrophage phenotype is in a …

The involvement of polyamines catabolism in the crosstalk between neurons and astrocytes in neurodegeneration

M Cervelli, M Averna, L Vergani, M Pedrazzi, S Amato… - Biomedicines, 2022 - mdpi.com
In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including
spermine, spermidine and putrescine, are involved in many cellular processes. Spermine …

Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A

P Gonzalez-Menendez, I Phadke… - Blood, The Journal …, 2023 - ashpublications.org
Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it
is not known whether the metabolic regulation of protein synthesis controls HSPC …

CLEC16A—An Emerging Master Regulator of Autoimmunity and Neurodegeneration

R Pandey, M Bakay, H Hakonarson - International Journal of Molecular …, 2023 - mdpi.com
CLEC16A is emerging as an important genetic risk factor for several autoimmune disorders
and for Parkinson disease (PD), opening new avenues for translational research and …