The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or …
Y Zhang, J Bai, Z Cui, Y Li, Q Gao, Y Miao, B Xiong - Nature Aging, 2023 - nature.com
Advanced age is a primary risk factor for female infertility due to reduced ovarian reserve and declining oocyte quality. However, as an important contributing factor, the role of …
S Kshirsagar, N Sawant, H Morton… - Human molecular …, 2022 - academic.oup.com
The purpose of our study is to determine the protective effects of mitophagy enhancers against mutant APP and amyloid beta (Aβ)-induced mitochondrial and synaptic toxicities in …
T Zhang, W Fu, H Zhang, J Li, B Xing, Y Cai… - Nature Cell …, 2024 - nature.com
It has been established that N-acetyltransferase (murine NAT1 (mNAT1) and human NAT2 (hNAT2)) mediates insulin sensitivity in type 2 diabetes. Here we show that mNAT1 …
M Tauc, M Cougnon, R Carcy, N Melis, T Hauet… - Cell & Bioscience, 2021 - Springer
Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and progression of …
Although different metabolic pathways have been associated with distinct macrophage phenotypes, the field of utilizing metabolites to modulate macrophage phenotype is in a …
M Cervelli, M Averna, L Vergani, M Pedrazzi, S Amato… - Biomedicines, 2022 - mdpi.com
In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including spermine, spermidine and putrescine, are involved in many cellular processes. Spermine …
P Gonzalez-Menendez, I Phadke… - Blood, The Journal …, 2023 - ashpublications.org
Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it is not known whether the metabolic regulation of protein synthesis controls HSPC …
R Pandey, M Bakay, H Hakonarson - International Journal of Molecular …, 2023 - mdpi.com
CLEC16A is emerging as an important genetic risk factor for several autoimmune disorders and for Parkinson disease (PD), opening new avenues for translational research and …