Neutrophil heterogeneity in cancer: from biology to therapies

P Lecot, M Sarabi, M Pereira Abrantes… - Frontiers in …, 2019 - frontiersin.org
Neutrophils have been extensively described in the pathophysiology of autoimmune and
infectious diseases. Accumulating evidence also suggests the important role of neutrophils …

Neutrophil extracellular traps in cancer: not only catching microbes

L Ronchetti, NS Boubaker, M Barba, P Vici… - Journal of Experimental …, 2021 - Springer
Neutrophils are the most abundant type of white blood cells circulating throughout the
bloodstream and are often considered the frontline defenders in innate immunity. However …

Mechanistic insights into the interplays between neutrophils and other immune cells in cancer development and progression

Z Mahmud, A Rahman, ID Mishu, Y Kabir - Cancer and Metastasis …, 2022 - Springer
Cancer is considered a major public health concern worldwide and is characterized by an
uncontrolled division of abnormal cells. The human immune system recognizes cancerous …

Neutrophils, cancer and thrombosis: The new Bermuda triangle in cancer research

M Langiu, AL Palacios-Acedo, L Crescence… - International Journal of …, 2022 - mdpi.com
Spontaneous venous thrombosis is often the first clinical sign of cancer, and it is linked to a
worsened survival rate. Traditionally, tumor-cell induced platelet activation has been the …

Predicting Immunotherapy outcomes in older patients with solid tumors using the LIPI score

M Pierro, C Baldini, E Auclin, H Vincent, A Varga… - Cancers, 2022 - mdpi.com
Simple Summary The Lung Immune Prognostic Index (LIPI) is a score that combines
pretreatment dNLR (neutrophils/(leukocytes− neutrophils) and lactate dehydrogenase (LDH) …

Pre-operative neutrophil-to-lymphocyte ratio is an independent prognostic factor in patients with gastric cancer

QY Han, X Zhang, JG Zhang, WJ Zhou, QY Chen… - International …, 2022 - Elsevier
Objective To evaluate the prognostic significance of peripheral lymphocyte count and its
derived inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), in a cohort of …

Gene signature of circulating platelet‐bound neutrophils is associated with poor prognosis in cancer patients

P Lecot, M Ardin, S Dussurgey… - … Journal of Cancer, 2022 - Wiley Online Library
Beyond their critical role in hemostasis, platelets physically interact with neutrophils to form
neutrophil‐platelet aggregates (NPAs), enhancing neutrophil effector functions during …

Role of annexin A1 secreted by neutrophils in melanoma metastasis

S Sandri, CB Hebeda, MF Broering, M de Paula Silva… - Cells, 2023 - mdpi.com
Annexin A1 (AnxA1) is highly secreted by neutrophils and binds to formyl peptide receptors
(FPRs) to trigger anti-inflammatory effects and efferocytosis. AnxA1 is also expressed in the …

Prognostic value of the lung immune prognosis index score for patients treated with immune checkpoint inhibitors for advanced or metastatic urinary tract carcinoma

P Parent, E Auclin, A Patrikidou, L Mezquita… - Cancers, 2023 - mdpi.com
Simple Summary In this report, we studied the role of the LIPI score, a biological score
based on 2 factors, derived neutrophils/(leukocytes minus neutrophils) ratio and lactate …

Neutrophils: accomplices in metastasis

K Zhu, P Li, Y Mo, J Wang, X Jiang, J Ge, W Huang… - Cancer Letters, 2020 - Elsevier
Metastasis is a critical cause of treatment failure and death in patients with advanced
malignancies. Tumor cells can leave the primary site and enter the bloodstream; these …