Primary cilia play a key role in the ability of cells to respond to extracellular stimuli, such as
signaling molecules and environmental cues. These sensory organelles are crucial to the …

Cells store excess energy in the form of lipid droplets (LDs), a specialized sub-compartment
of the endoplasmic reticulum (ER) network. The lipodystrophy protein seipin is a key player …

Astrocytes, often considered as secondary responders to neurodegeneration, are emerging
as primary drivers of brain disease. Here we show that mitochondrial DNA depletion in …

Nephronophthisis (NPH) is an autosomal recessive tubulointerstitial nephropathy belonging
to the ciliopathy disorders and known as the most common cause of hereditary end-stage …

Cilia are microtubule-based organelles that project from the cell surface with motility or
sensory functions. Primary cilia work as antennae to sense and transduce extracellular …

Cilia are microtubule‐based organelles that protrude from the cell surface and play crucial
roles in cellular signaling pathways and extracellular fluid movement. Defects in the ciliary …

Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular
cues and transduce signals into the cell to regulate a wide range of functions. Lipid rafts …

Primary open-angle glaucoma (POAG) is a complex eye disease characterized by
progressive loss of optic nerve function that, if untreated, ultimately leads to irreversible …

The search for causative mutations in human genetic disorders has mainly focused on
mutations that disrupt coding regions or splice sites. Recently, however, it has been reported …

Neural progenitors and their neuronal progeny are bathed in extrinsic signals that impact
critical decisions like the mode of cell division, how long they should reside in specific …