Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …

Protein kinases are highly tractable targets for drug discovery. However, the biological
function and therapeutic potential of the majority of the 500+ human protein kinases remains …

New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Within the liver a single Plasmodium parasite transforms into thousands of blood-infective
forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are …

Over 20 years after the approval of the first-in-class protein kinase inhibitor imatinib, the
biological function of a significant fraction of the human kinome remains poorly understood …

New strategies are urgently needed to counter the threat to human health posed by drug-
resistant fungi. To explore an as-yet unexploited target space for antifungals, we screened a …

Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-
line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as …

Background Malaria, a disease caused by parasites of the genus Plasmodium, continues to
impact many regions globally. The rise in resistance to artemisinin-based anti-malarial drugs …

The need for novel antimalarials is apparent given the continuing disease burden
worldwide, despite significant drug discovery advances from the bench to the bedside. In …