Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate
protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin …

Proteasome inhibitors have been actively tested as potential anticancer drugs and in the
treatment of inflammatory and autoimmune diseases. Unfortunately, cells adapt to survive in …

The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …

Polo-like kinase (PLK) 2 is an evolutionarily conserved serine/threonine kinase that shares
the n-terminal kinase catalytic domain and the C-terminal Polo Box Domain (PBD) with other …

Recent evidence suggests the global incidence and mortality of hepatocellular carcinoma
(HCC) are increasing. Although the highest incidence of HCC remains entrenched in WHO …

Abstract Background Loss of UBE3A causes Angelman syndrome, whereas excess UBE3A
activity appears to increase the risk for autism. Despite this powerful association with …

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder in the old
population. Among its monogenic variants, a frequent cause is a mutation in the Parkin gene …

PPP1R21 acts as a co-factor for protein phosphatase 1 (PP1), an important serine/threonine
phosphatase known to be essential for cell division, control of glycogen metabolism, protein …

Introduction Methamphetamine (METH) is a psychostimulant drug with complicated
neurotoxicity, and abuse of METH is very common. Studies have shown that METH …

One of the most fascinating features of the brain is its ability to adapt to its surroundings.
Synaptic plasticity, the dynamic mechanism of functional and structural alterations in …