Eph receptor tyrosine kinases and their ephrin ligands are involved in various signalling
pathways and mediate critical steps of a wide variety of physiological and pathological …

The subcellular localization of a protein is closely linked to and indicates its function. The
metastatic tumor antigen (MTA) family has been under continuous investigation since its …

Pancreatic β cell failure in type 2 diabetes is associated with functional abnormalities of
insulin secretion and deficits of β cell mass. It's unclear how one begets the other. We have …

Abstract Hypermethylated in cancer 1 (HIC1) is a tumour suppressor gene that is frequently
deleted or epigenetically silenced in many human cancers. However, the molecular function …

HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene frequently epigenetically
silenced in human cancers. HIC1 encodes a transcriptional repressor involved in the …

Abstract Hypermethylated-in-Cancer 1 (Hic1) is a tumor suppressor gene frequently
inactivated by epigenetic silencing and loss-of-heterozygosity in a broad range of cancers …

HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene epigenetically silenced or
deleted in many human cancers. HIC1 is involved in regulatory loops modulating p53-and …

Introduction: The tumor suppressor gene HIC1 (Hypermethylated in Cancer 1), which
encodes a transcriptional repressor with multiple partners and multiple targets, is …

Hypermethylation leading to the loss of hypermethylated in cancer-1 (HIC1) gene
expression occurs in many different types of human cancer. HIC1 is a transcriptional …

Loss of ephrin receptor (EphB1) expression may associate with aggressive cancer
phenotypes; however, the mechanism of action remains unclear. To gain detailed insight …