Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Toxicology and pharmacology of synthetic organoselenium compounds: An update
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …
compounds and some naturally occurring organoselenium amino acids. The use of …
Rare and common genetic determinants of metabolic individuality and their effects on human health
P Surendran, ID Stewart, VPW Au Yeung, M Pietzner… - Nature Medicine, 2022 - nature.com
Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …
molecular origins of human diseases. Untargeted high-throughput metabolomic …
An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study
S Yuan, SC Larsson - Diabetologia, 2020 - Springer
Aims/hypothesis The aim of this study was to use Mendelian randomisation (MR) to identify
the causal risk factors for type 2 diabetes. Methods We first conducted a review of meta …
the causal risk factors for type 2 diabetes. Methods We first conducted a review of meta …
Mendel's laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues
We respond to criticisms of Mendelian randomization (MR) by Mukamal, Stampfer and Rimm
(MSR). MSR consider that MR is receiving too much attention and should be renamed. We …
(MSR). MSR consider that MR is receiving too much attention and should be renamed. We …
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome
The intestinal microbiome is implicated as an important modulating factor in multiple
inflammatory,, neurologic and neoplastic diseases. Recent genome-wide association …
inflammatory,, neurologic and neoplastic diseases. Recent genome-wide association …
[HTML][HTML] Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials
Background Antioxidants have been promoted for cardiovascular disease (CVD) risk
reduction and for the prevention of cancer. Our preliminary analysis suggested that only …
reduction and for the prevention of cancer. Our preliminary analysis suggested that only …
A systematic review and dose-response meta-analysis of exposure to environmental selenium and the risk of type 2 diabetes in nonexperimental studies
Accumulating evidence from both experimental and nonexperimental human studies in the
last 15 years indicates that exposure to high levels of the trace element selenium increases …
last 15 years indicates that exposure to high levels of the trace element selenium increases …
The critical role of passive permeability in designing successful drugs
Passive permeability is a key property in drug disposition and delivery. It is critical for
gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance …
gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance …
Identifying novel causes of cancers to enhance cancer prevention: new strategies are needed
P Brennan, G Davey-Smith - JNCI: Journal of the National …, 2022 - academic.oup.com
The burden of cancer from a clinical, societal, and economic viewpoint continues to increase
in all parts of the world, along with much debate regarding how to confront this. Projected …
in all parts of the world, along with much debate regarding how to confront this. Projected …