Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

ContextThroughout the past 40 years, a vast and sometimes contradictory literature has
accumulated regarding hypertrophic cardiomyopathy (HCM), a genetic cardiac disease …

ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2)
isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels …

For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …

Background—Hypertrophic cardiomyopathy is an autosomal-dominant disorder in which 10
genes and numerous mutations have been reported. The aim of the present study was to …

The heart exhibits remarkable adaptive responses to a wide array of genetic and extrinsic
factors to maintain contractile function. When compensatory responses are not sustainable …

Currently, five different statins (simvastatin, pravastatin, lovastatin, fluvastatin, and
atorvastatin) are approved for treatment of hypercholesterolemia in humans and two new …

Objectives: The purpose of this study was to examine the patient-specific characteristics of
the interleukin-1 receptor family member ST2 in patients with acute heart failure (HF) …

Volume 1 of Circulation provides an excellent snapshot of the understanding of the
mechanisms and treatment of heart failure a half century ago. During that era, circulatory …

Objectives: We sought to ascertain whether myocardial scarring occurs in living unselected
patients with hypertrophic cardiomyopathy (HCM). Background: Myocardial scarring is …