Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …

Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …

Metabolic reprogramming is a hallmark of cancer. However, it is not well known how
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …

WNT/β-catenin signaling orchestrates various physiological processes, including embryonic
development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin …

BACKGROUND: SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect
the kidneys and heart, but the underlying mechanism remains poorly understood …

Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …

The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

Aberrant Wnt signaling activation is frequently observed in many cancers. The mutation
acquisition of Wnt signaling leads to tumorigenesis, whereas the inhibition of Wnt signaling …