SOX9 in organogenesis: shared and unique transcriptional functions
The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …
Single-cell transcriptome analysis maps the developmental track of the human heart
The heart is the central organ of the circulatory system, and its proper development is vital
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …
Signaling pathways regulating cartilage growth plate formation and activity
WE Samsa, X Zhou, G Zhou - Seminars in cell & developmental biology, 2017 - Elsevier
The growth plate is a highly specialized and dynamic cartilage structure that serves many
essential functions in skeleton patterning, growth and endochondral ossification in …
essential functions in skeleton patterning, growth and endochondral ossification in …
Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing
Y Zeng, J He, Z Bai, Z Li, Y Gong, C Liu, Y Ni, J Du… - Cell research, 2019 - nature.com
Tracing the emergence of the first hematopoietic stem cells (HSCs) in human embryos,
particularly the scarce and transient precursors thereof, is so far challenging, largely due to …
particularly the scarce and transient precursors thereof, is so far challenging, largely due to …
Transcriptomic profiling maps anatomically patterned subpopulations among single embryonic cardiac cells
Embryonic gene expression intricately reflects anatomical context, developmental stage,
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …
[HTML][HTML] Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development
The current understanding of mammalian kidney development is largely based on mouse
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …
Cell diversity and plasticity during atrioventricular heart valve EMTs
Epithelial-to-mesenchymal transitions (EMTs) of both endocardium and epicardium guide
atrioventricular heart valve formation, but the cellular complexity and small scale of this …
atrioventricular heart valve formation, but the cellular complexity and small scale of this …
In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures
M Rahmoun, R Lavery… - Nucleic acids …, 2017 - academic.oup.com
In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that
orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9 …
orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9 …
SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis
ABSTRACT SOX9 controls cell lineage fate and differentiation in major biological processes.
It is known as a potent transcriptional activator of differentiation-specific genes, but its …
It is known as a potent transcriptional activator of differentiation-specific genes, but its …
SOX9: A genomic view of tissue specific expression and action
A Symon, V Harley - The International Journal of Biochemistry & Cell …, 2017 - Elsevier
The SOX9 transcription factor controls the differentiation of many cell types among
vertebrates. The SOX9 gene locus is large and complex and contains various tissue-specific …
vertebrates. The SOX9 gene locus is large and complex and contains various tissue-specific …