Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

Progress toward the development of efficacious therapies for Alzheimer's disease (AD) is
halted by a lack of understanding early underlying pathological mechanisms. Systems …

Autism spectrum disorder (ASD) refers to a group of complex neurodevelopmental disorders
characterized by social interaction and communication deficits and repetitive and …

Detection of metabolic activity enables us to reveal the inherent metabolic state of cells and
elucidate mechanisms underlying cellular homeostasis and growth. However, a …

Medical research has been revolutionized after the publication of the full human genome.
This was the major landmark that paved the way for understanding the biological functions …

Volatolomics allows us to elucidate cell metabolic processes in real time. In particular, a
volatile organic compound (VOC) excreted from our bodies may be specific for a certain …

Constipation is one of the most common gastrointestinal disorders, whose incidence
increasing with age. As one of the main components, Astragalus polysaccharide (APS) has …

In this study, we present the potential application of deuterium-depleted water (DDW) for the
prevention and adjuvant treatment of obesity in rats. We tested the hypothesis that DDW can …

Alterations in the metabolism of substrates such as glucose are integrally linked to the
structural and functional changes that occur in the remodeling heart. Assessment of such …

Age-related hearing loss (ARHL) is the most prevalent sensory disorder in the elderly.
Currently, no treatment can effectively prevent or reverse ARHL. Aging auditory organs are …